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"冷"蛋白TRPM8抗体
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

转化受体电位阳离子通道亚家族M成员8(TRPM8)抗体
Anti-TRPM8
靶标:

TRPM8


产品别名:

LTRPC6; LTrpC-6; TRPP8; trp-p8; TRPM8; transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel subfamily M member 8; TRPM8 cationic channel; transient receptor potential p8; transient receptor potential subfamily M member 8; “冷”蛋白TRPM8; 转化受体电位阳离子通道亚家族M成员8(TRPM8);


背景信息:
function:Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.,miscellaneous:Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.,miscellaneous:The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.,similarity:Belongs to the transient receptor family. LTrpC subfamily.,tissue specificity:Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.,
 
 
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