靶标:
ADAMTS10
产品别名:
ADAM-TS10; ADAMTS-10; WMS; WMS1; ADAMTS10; ADAM metallopeptidase with thrombospondin type 1 motif 10; ADAM metallopeptidase with thrombospondin type 1 motif 10; A disintegrin and metalloproteinase with thrombospondin motifs 10; ADAM-TS 10; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10; zinc metalloendopeptidase; 整合素样金属蛋白酶与凝血酶10型; 血小板反应蛋白解整合素金属肽酶10(ADAMTS10);
背景信息:
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008],