靶标：
CCM2
产品别名：
C7orf22； OSM； PP10187； CCM2； CCM2 scaffold protein； CCM2 scaffold protein； cerebral cavernous malformations 2 protein； CCM2 scaffolding protein； cerebral cavernous malformation 2； malcavernin； osmosensing scaffold for MEKK3； 脑海绵状血管畸形蛋白2；
背景信息：
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
