靶标:
SETDB2
产品别名:
C13orf4; CLLD8; CLLL8; KMT1F; SETDB2; SET domain bifurcated histone lysine methyltransferase 2; SET domain bifurcated histone lysine methyltransferase 2; histone-lysine N-methyltransferase SETDB2; SET domain bifurcated 2; chronic lymphocytic leukemia deletion region gene 8 protein; lysine N-methyltransferase 1F; 组蛋白H3-K9甲基转移酶;
背景信息:
SET domain bifurcated 2(SETDB2) Homo sapiens This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],