靶标：
Uhrf2
产品别名：
2310065A22Rik； AI426270； AW214556； D130071B19Rik； Nirf； Uhrf2； ubiquitin-like, containing PHD and RING finger domains 2； ubiquitin-like, containing PHD and RING finger domains 2； E3 ubiquitin-protein ligase UHRF2； Np95-like ring finger protein； RING-type E3 ubiquitin transferase UHRF2； nuclear protein 97； nuclear zinc finger protein Np97； ubiquitin-like PHD and RING finger domain-containing protein 2； ubiquitin-like-containing PHD and RING finger domains protein 2； 环指蛋白107；
背景信息：
E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene. This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
