靶标:
ACVR1C
产品别名:
ACVRLK7; ALK7; ACVR1C; activin A receptor type 1C; activin A receptor type 1C; activin receptor type-1C; ACTR-IC; ALK-7; activin A receptor, type IC; activin receptor type IC; activin receptor-like kinase 7; 激活素A受体ⅠC(ACVR1C); 激活素受体1C;
背景信息:
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008],