靶标：
Gdf6
产品别名：
BMP-13； BMP13； GDF16； Gdf6； growth differentiation factor 6； growth differentiation factor 6； growth/differentiation factor 6； GDF-6； bone morphogenetic protein 13； growth/differentiation factor 16； 生长分化因子6； 生长分化因子6(GDF6)；
背景信息：
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis. [provided by RefSeq, Sep 2016],
