靶标：
AFF3
产品别名：
KINS； LAF4； MLLT2-like； AFF3； ALF transcription elongation factor 3； ALF transcription elongation factor 3； AF4/FMR2 family member 3； MLLT2-related protein； lymphoid nuclear protein 4； lymphoid nuclear protein related to AF4； protein LAF-4；
背景信息：
AFF3 is a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL.This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
