靶标：
IRAG1
产品别名：
IRAG； JAW1L； MRVI1； IRAG1； inositol 1,4,5-triphosphate receptor associated 1； inositol 1,4,5-triphosphate receptor associated 1； inositol 1,4,5-triphosphate receptor associated 1； IP3R-associated cGMP kinase substrate； JAW1-related protein MRVI1； inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate； inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate； murine retrovirus integration site 1 homolog； MRVI1蛋白；
背景信息：
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV).The encoded protein, which is found inThe membrane ofThe endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation.This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by alteringThe expression of a gene important for myeloid cell growth and/or differentiation, and thusThis gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found forThis gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
