靶标：
SIPA1L3
产品别名：
CTRCT45； SPAL3； SPAR3； SIPA1L3； signal induced proliferation associated 1 like 3； signal induced proliferation associated 1 like 3； signal-induced proliferation-associated 1-like protein 3； SIPA1-like protein 3； SPA-1-like protein 3； spine-associated RapGAP 3； 信号诱导增殖相关蛋白1样蛋白3；
背景信息：
Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.
