靶标：
ARHGAP8
产品别名：
BPGAP1； PP610； ARHGAP8； Rho GTPase activating protein 8； Rho GTPase activating protein 8； rho GTPase-activating protein 8； BCH domain-containing Cdc42GAP-like protein； BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1； rho-type GTPase-activating protein 8；
背景信息：
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
