Noto is a transcription regulator acting downstream of both FOXA2 and T during notochord development.Noto is required for node morphogenesis.Noto is essential for cilia formation inThe posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 inThis process and is required forThe expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.