Anti-Atp8a2
Anti-ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 Antibody
靶标：
Atp8a2
产品别名：
AI415030； Atpc1b； agil； wl； Atp8a2； ATPase, aminophospholipid transporter-like, class I, type 8A, member 2； ATPase, aminophospholipid transporter-like, class I, type 8A, member 2； phospholipid-transporting ATPase IB； ATPase 8A2, class I； ATPase 8A2, p type； ATPase class I type 8A member 2； ATPase, class 1, member a； P4-ATPase flippase complex alpha subunit ATP8A2； probable phospholipid-transporting ATPase IB；
背景信息：
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
