靶标：
LRFN2
产品别名：
FIGLER2； KIAA1246； SALM1； LRFN2； leucine rich repeat and fibronectin type III domain containing 2； leucine rich repeat and fibronectin type III domain containing 2； leucine-rich repeat and fibronectin type-III domain-containing protein 2； fibronectin type III, immunoglobulin and leucine rich repeat domains 2； synaptic adhesion-like molecule 1； 神经突触粘附样分子1；
背景信息：
LRFN2 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.
