靶标:
Aph1c
产品别名:
0610008A10Rik; APH-1b; Aph1b; Aph1c; aph1 homolog C, gamma secretase subunit; aph1 homolog C, gamma secretase subunit; putative gamma-secretase subunit APH-1C; anterior pharynx defective 1b; anterior pharynx defective 1c homolog;
背景信息:
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.