靶标：
Fbxl15
产品别名：
0710008C12Rik； Fbxo37； Fbxl15； F-box and leucine-rich repeat protein 15； F-box and leucine-rich repeat protein 15； F-box/LRR-repeat protein 15； F-box only protein 37； FBXL15蛋白；
背景信息：
FBXL15 is a substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance and also mediates ubiquitination of SMURF2 and WWP2.
