靶标：
Castor1
产品别名：
2410008K03Rik； Gatsl3； Castor1； cytosolic arginine sensor for mTORC1 subunit 1； cytosolic arginine sensor for mTORC1 subunit 1； cytosolic arginine sensor for mTORC1 subunit 1； GATS protein-like 3； GATS-like protein 3；
背景信息：
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
