靶标：
Cmya5
产品别名：
2310076E16Rik； 2310076E21Rik； AA420382； AI504003； Srfsd； Tims； sr553； Cmya5； cardiomyopathy associated 5； cardiomyopathy associated 5； cardiomyopathy-associated protein 5； TRIM-like protein； heart and skeletal muscle-specific and sprouty domain-containing； myospryn； stretch response protein 553； stretch-responsive fibronectin protein type 3；
背景信息：
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
