靶标:
THSD4
产品别名:
AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334; PRO34005; THSD4; thrombospondin type 1 domain containing 4; thrombospondin type 1 domain containing 4; thrombospondin type-1 domain-containing protein 4; A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6; ADAMTS-like protein 6; thrombospondin, type I, domain containing 4;
背景信息:
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity.