靶标：
RGPD5
产品别名：
BS-63； BS63； HEL161； RGP5； RGPD5； RANBP2 like and GRIP domain containing 5； RANBP2 like and GRIP domain containing 5； RANBP2-like and GRIP domain-containing protein 5/6； RANBP2-like and GRIP domain-containing protein 5； epididymis luminal protein 161； ran-binding protein 2-like 1； ran-binding protein 2-like 1/2； ranBP2-like 1； ranBP2-like 1/2； ranBP2L1； sperm membrane protein BS-63； Ran结合蛋白2样蛋白1；
背景信息：
The RANBP2-like and GRIP domain containing 5 protein (RGPD5) has high similarity to RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. The gene coding for RGPD5 is thought to have arisen from a gene duplication event of RANBP2 as these highly homologous genes are located close to each other at chromosome 2q11-q12. RGPD5 was identified as an HIV dependency factor (HDF), suggesting that RGPD5 may be an important drug target in HIV treatment. At least two isoforms of RGPD5 are known to exist, of which the shorter isoform is expressed primarily in testis, while the longer of the two is expressed at low levels in a number of somatic tissues.
