靶标：
ARHGAP11B
产品别名：
B'-T； FAM7B1； GAP (1-8)； ARHGAP11B； Rho GTPase activating protein 11B； Rho GTPase activating protein 11B； inactive Rho GTPase-activating protein 11B； family with sequence similarity 7, member B1； rho GTPase-activating protein 11B； rho-type GTPase-activating protein 11B；
背景信息：
Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP: delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+ concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
