The SLC2 family of glucose and polyol transporters comprises 13 members, the glucose transporters (GLUT) 1-12 and the H(⁺)- myo-inositol cotransporter (HMIT). These proteins all contain 12 transmembrane domains with both the amino and carboxy-terminal ends located on the cytoplasmic side of the plasma membrane and an N-linked oligosaccharide side-chain located either on the first or fifth extracellular loop. GLUT7 (also known as GLUT7; GLUT-7; hGLUT7) is primarily expressed in the small intestine and colon, although mRNA has been detected in the testis and prostate as well. The GLUT7 protein is expressed in the apical membrane of the small intestine and colon, and it has a high affinity for glucose and fructose.