靶标:
TTLL8
产品别名:
TTLL8; tubulin tyrosine ligase like 8; tubulin tyrosine ligase like 8; protein monoglycylase TTLL8; tubulin tyrosine ligase-like family, member 8; tubulin--tyrosine ligase-like protein 8;
背景信息:
Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity).