靶标:
Dars
产品别名:
5730439G15Rik; Dars1; Dars; aspartyl-tRNA synthetase; aspartyl-tRNA synthetase; aspartate--tRNA ligase, cytoplasmic; aspRS; aspartyl-tRNA synthetase, cytoplasmic; 天冬氨酰tRNA合成酶(DARS);
背景信息:
Aspartate tRNA ligase 1, also known as DARS, is part of a multienzyme complex of aminoacyl-tRNA synthetases. It belongs to the class-II aminoacyl-tRNA synthetase family. DARS charges its cognate tRNA with aspartate during protein biosynthesis. DARS catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid(AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.