The kinesin superfamily proteins (KIFs) are microtubule-dependent molecular motors that transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner. Cells use KIFs to tightly control the direction, destination, and speed of transportation of a variety of important functional molecules, including mRNA. KIFC2 is 792 amino acid member of the C-terminal motor family specifically expressed in both the central and peripheral nervous systems in nonproliferative cells. KIFC2 accumulates at the proximal and distal sides of axons and is a minus-end-directed kinesin. KIFC2 localizes with some, but not all, axonally transported organelles. KIFC2 may be involved in retrograde axonal transport.