SCAND2 is a 306 amino acid nuclear protein that may play a role in the mechanism of transcriptional regulation. SCAND2 contains one SCAN box domain and, unlike most SCAN box domain-containing proteins, is devoid of a C2H2-type zinc-finger domain. The SCAN box domain is a conserved leucine rich motif, approximately 60 amino acids in length, that participates in protein-protein interactions. The SCAND2 gene is a fusion gene created by the retropositioning of a PHD2 (also known as EGLN1) gene copy from chromosome 1 onto an ancestral SCAN zinc finger gene, followed by exon shuffling. The resulting SCAND2 gene product has an N-terminal SCAN domain and a C-terminus derived from the PHD2 gene. SCAND2 exists as 2 isoforms produced by alternative splicing.