The INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication. Evolutionarily conserved from yeast to human, theINO80 complex belongs to a subfamily of the ATP-dependent chromatin remodelers and is characterized by a split ATPase domain in the core ATPase subunit. ATP-dependent chromatin remodeling complexes contain ATPases of the Swi/Snf superfamily and alter DNA accessibility of chromatin in an ATP-dependent manner. INO80D (INO80 complex subunit D), is an 878 amino acid protein that is a component of the chromatin-remodeling INO80 complex.