基因名:
DSCAML1
产品别名:
DSCAM2; DSCAML1; DS cell adhesion molecule like 1; DS cell adhesion molecule like 1; Down syndrome cell adhesion molecule-like protein 1; DSCAM-like 1; Downs syndrome cell adhesion molecule like 1; down syndrome cell adhesion molecule 2; 唐氏综合症细胞粘附分子2;
背景信息:
DSCAML1 is a cell adhesion molecule that contains six Fibronectin type-III domains and ten Ig-like C2-type domains. DSCAML1 is involved in regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). DSCAML1 also promotes heteroneuronal self-avoidance to maintain mosaic spacing between aII amacrine cells. DSCAML1 is expressed in liver, skeletal muscle, brain, kidney, pancreas and heart and exists as two isoforms produced by alternative splicing events.