基因名:
MICAL3
产品别名:
MICAL-3; MICAL3; microtubule associated monooxygenase, calponin and LIM domain containing 3; microtubule associated monooxygenase, calponin and LIM domain containing 3; [F-actin]-monooxygenase MICAL3; [F-actin]-methionine sulfoxide oxidase MICAL3; flavoprotein oxidoreductase MICAL3; molecule interacting with CasL protein 3; protein MICAL-3; protein-methionine sulfoxide oxidase MICAL3; MICAL3蛋白;
背景信息:
MICAL3 is a 976 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Expressed ubiquitously, MICAL3 uses FAD as a cofactor to interact with Rab 1B and, via this interaction, is thought to play a role in spermatid development. MICAL3 exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 22. Chromosome 22 houses over 500 genes, some of which are involved in Phelan-McDermid syndrome, schizophrenia and Neurofibromatosis type 2.