基因名：
Nacc2
产品别名：
0610020I02Rik； AI448087； Btbd14a； C030048H19Rik； Nacc2； nucleus accumbens associated 2, BEN and BTB (POZ) domain containing； nucleus accumbens associated 2, BEN and BTB (POZ) domain containing； nucleus accumbens-associated protein 2； BTB (POZ) domain containing 14A； BTB/POZ domain-containing protein 14A； NAC-2； BTBD14A蛋白；
背景信息：
BTBD14A is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.
