FLYWCH1 (FLYWCH-type zinc finger 1) is a 716 amino acid nuclear protein containing five FLYWCH-type zinc fingers. Existing as five alternatively spliced isoforms, FLYWCH1 is encoded by a gene located on human chromosome 16p13.3. Chromosome 16 encodes over 900 genes and comprises nearly 3% of human cellular DNA. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16 through the CREBBP gene, which encodes a critical CREB binding protein. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.