基因名：
Dnah12
产品别名：
4921531P07Rik； DHC3； DLP12； Dnah12l； Dnahc12； Dnahc3； Dnahc7c； Dnahc7l； Gm284； Gm74； Gm907； HL-19； HL19； Hdhc3； Dnah12； dynein, axonemal, heavy chain 12； dynein, axonemal, heavy chain 12； dynein axonemal heavy chain 12； dynein heavy chain 12, axonemal； axonemal beta dynein heavy chain 12； axonemal dynein heavy chain 12-like protein； axonemal dynein heavy chain 7-like protein； ciliary dynein heavy chain 12； dynein, axonemal, heavy chain 3； 轴丝动力蛋白12；
背景信息：
Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; complexes that transport cellular cargo toward the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH12 is a 3,092 amino acid protein of cilium axoneme that exists as three alternatively spliced isoforms. A member of the dynein heavy chain family, DNAH12L is involved in sperm flagellar assembly and is encoded by a gene located on human chromosome 3.
