| 规格: | ≥98% |
| Molecular Weight (MW) | 448.56 |
|---|---|
| Formula | C27H32lN2O4 |
| CAS No. | NA |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 10mM |
| Water: NA | |
| Ethanol: NA | |
| Chemical Name | N-(2-((2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide |
| Synonyms | BMS-37; BMS 37; BMS37 |
| SMILES Code | CC(NCCNCC1=C(OC)C=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)C=C1OC)=O |
| In Vitro | In vitro activity: BMS-1001 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 protein protein interaction with IC50 value of 2.25 nM in cell free assays. Kinase Assay: BMS disclosed recently the first nonpeptidic small molecule inhibitors against the PD-1/PD-L1 pathway that showed the activity in a homogeneous time-resolved fluorescence (HTRF) binding assay; however no further data supporting their activity were provided. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
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