重组磷酸化非受体酪氨酸激酶c-Abl蛋白

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重组非受体酪氨酸激酶c-Abl蛋白
Recombinant ABL1

基因名：

ABL1

产品别名：

ABL； BCR-ABL； CHDSKM； JTK7； bcr/abl； c-ABL； c-ABL1； p150； v-abl； ABL1； ABL proto-oncogene 1, non-receptor tyrosine kinase； ABL proto-oncogene 1, non-receptor tyrosine kinase； tyrosine-protein kinase ABL1； ABL protooncogene 1 nonreceptor tyrosine kinase； Abelson tyrosine-protein kinase 1； BCR-ABL1 p190； BCR/ABL e8a2 fusion； BCR/ABL1 e1a2 fusion protein； bcr/c-abl oncogene protein； c-abl oncogene 1, receptor tyrosine kinase； proto-oncogene c-Abl； proto-oncogene tyrosine-protein kinase ABL1； v-abl Abelson murine leukemia viral oncogene homolog 1；磷酸化非受体酪氨酸激酶c-Abl；非受体酪氨酸激酶c-Abl；

背景信息：

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。