基因名：
ACACB
产品别名：
ACACbeta； ACC-beta； ACC2； ACCB； ACCbeta； HACC275； ACACB； acetyl-CoA carboxylase beta； acetyl-CoA carboxylase beta； acetyl-CoA carboxylase 2； acetyl-Coenzyme A carboxylase beta； 乙酰辅酶A羧化酶； 乙酰辅酶A羧化酶1/ACCα； 乙酰辅酶A羧化酶β(ACACb)； 磷酸化乙酰辅酶A羧化酶； 磷酸化乙酰辅酶A羧化酶1ACCα；
背景信息：
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
