基因名：
ASIC1
产品别名：
ACCN2； ASIC； BNaC2； ASIC1； acid sensing ion channel subunit 1； acid sensing ion channel subunit 1； acid-sensing ion channel 1； Cation channel, amiloride-sensitive, neuronal, 2； acid sensing (proton gated) ion channel 1； acid-sensing ion channel 1a protein； amiloride-sensitive cation channel 2, neuronal； brain sodium channel 2； 脑钠通道蛋白2； 酸敏感离子通道1；
背景信息：
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
