基因名：
ACVR1B
产品别名：
ACTRIB； ACVRLK4； ALK4； SKR2； ACVR1B； activin A receptor type 1B； activin A receptor type 1B； activin receptor type-1B； activin A receptor, type IB； activin A receptor, type II-like kinase 4； activin receptor-like kinase 4； serine/threonine-protein kinase receptor R2； 激活素A受体1B； 激活素A受体ⅠB(ACVR1B)； 激活素受体1B；
背景信息：
Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.
