基因名：
TLE5
产品别名：
AES； AES-1； AES-2； ESP1； GRG； GRG5； Grg-5； TLE5； TLE family member 5, transcriptional modulator； TLE family member 5, transcriptional modulator； TLE family member 5； amino-terminal enhancer of split； gp130-associated protein GAM； groucho-related protein 5； gp130结合蛋白GAM；
背景信息：
TLE5 is a 197 amino acid nuclear protein that belongs to the TLE family. Expressed predominately in fetal brain, liver, lung, heart and kidney and in adult muscle, TLE5 functions as either a homooligomer or a heterooligomer with other TLE family members and, through this association, dominantly represses the expression of TLE genes. In addition, TLE5 can repress NFkB-regulated gene expression and is thought to play an important role in initiating and maintaining cell differentiation events. Two isoforms of TLE5 exist due to alternative splicing events.
