基因名：
ACAN
产品别名：
AGC1； AGCAN； CSPG1； CSPGCP； MSK16； SEDK； SSOAOD； ACAN； aggrecan； aggrecan； aggrecan core protein； cartilage-specific proteoglycan core protein； chondroitin sulfate proteoglycan core protein 1； large aggregating proteoglycan； 短蛋白聚糖； 聚集蛋白聚糖(AGC)； 软骨蛋白聚糖； 软骨蛋白聚糖核心蛋白；
背景信息：
Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
