基因名:
ALDH9A1
产品别名:
ALDH4; ALDH7; ALDH9; E3; TMABA-DH; TMABADH; TMABALDH; ALDH9A1; aldehyde dehydrogenase 9 family member A1; aldehyde dehydrogenase 9 family member A1; 4-trimethylaminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase; aldehyde dehydrogenase (NAD+); aldehyde dehydrogenase E3 isozyme; aldehyde dehydrogenase family 9 member A1; gamma-aminobutyraldehyde dehydrogenase; γ-氨基丁酸醛脱氢酶; 醛脱氢酶9家族成员A1(ALDH9A1);
背景信息:
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH9A1 (aldehyde dehydrogenase family 9 member A1), also known as E3, ALDH4, ALDH7, ALDH9 or TMABADH, is a 494 amino acid cytoplasmic protein that is highly expressed in adult liver, skeletal muscle, kidney and embryonic brain. ALDH9A1 converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine and catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in a NAD-dependent reaction.