基因名：
BIN1
产品别名：
AMPH2； AMPHL； CNM2； SH3P9； BIN1； bridging integrator 1； bridging integrator 1； myc box-dependent-interacting protein 1； amphiphysin II； amphiphysin-like protein； box dependant MYC interacting protein 1； box-dependent myc-interacting protein 1； 桥连整合因子1(BIN1)； 桥连整合因子蛋白；
背景信息：
The identification and analysis of tumor suppressors is of major importance for improved diagnosis and treatment of tumors. Bin1 (Box-dependent myc interacting protein 1, also known as SH3P9, amphiphysin II and amphl/amphiphysin-like) is a novel protein that has features of a tumor suppressor. Bin1 interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Bin1 also interacts with HCV NS5A through its SH3 domain.
