基因名：
APAF1
产品别名：
APAF-1； CED4； APAF1； apoptotic peptidase activating factor 1； apoptotic peptidase activating factor 1； apoptotic protease-activating factor 1； 凋亡蛋白活性因子-1（C端）； 凋亡蛋白活性因子-1（N端）； 凋亡蛋白酶激活因子1(APAF1)；
背景信息：
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain(NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
