基因名：
APBA1
产品别名：
D9S411E； LIN10； MINT1； X11； X11A； X11ALPHA； APBA1； amyloid beta precursor protein binding family A member 1； amyloid beta precursor protein binding family A member 1； amyloid-beta A4 precursor protein-binding family A member 1； adapter protein X11alpha； adaptor protein X11alpha； amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)； mint-1； neuron-specific X11 protein； neuronal munc18-1-interacting protein 1； phosphotyrosine-binding/-interacting domain (PTB)-bearing protein； β淀粉样前体蛋白结合蛋白1（X11α）；
背景信息：
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11a (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).
