重组多功能DNA修复酶蛋白

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重组多功能DNA修复酶蛋白

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重组脱嘌呤/脱嘧啶核酸内切酶1(APEX1)蛋白
Recombinant APEX1

基因名：

APEX1

产品别名：

APE； APE1； APEN； APEX； APX； HAP1； REF1； APEX1； apurinic/apyrimidinic endodeoxyribonuclease 1； apurinic/apyrimidinic endodeoxyribonuclease 1； DNA-(apurinic or apyrimidinic site) endonuclease； AP endonuclease class I； AP lyase； APEX nuclease (multifunctional DNA repair enzyme) 1； DNA-(apurinic or apyrimidinic site) lyase； apurinic-apyrimidinic endonuclease 1； apurinic/apyrimidinic (abasic) endonuclease； deoxyribonuclease (apurinic or apyrimidinic)； protein REF-1； redox factor-1；多功能DNA修复酶；脱嘌呤/脱嘧啶核酸内切酶1(APEX1)；

背景信息：

Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.