基因名：
XIAP
产品别名：
API3； BIRC4； IAP-3； ILP1； MIHA； XLP2； hIAP-3； hIAP3； XIAP； X-linked inhibitor of apoptosis； X-linked inhibitor of apoptosis； E3 ubiquitin-protein ligase XIAP； IAP-like protein 1； RING-type E3 ubiquitin transferase XIAP； X-linked IAP； X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase； baculoviral IAP repeat-containing protein 4； inhibitor of apoptosis protein 3； X-连锁凋亡蛋白/性连锁凋亡抑制蛋白； X-连锁凋亡蛋白抑制因子(XIAP)；
背景信息：
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
