基因名：
APP
产品别名：
AAA； ABETA； ABPP； AD1； APPI； CTFgamma； CVAP； PN-II； PN2； alpha-sAPP； preA4； APP； amyloid beta precursor protein； amyloid beta precursor protein； amyloid-beta precursor protein； alzheimer disease amyloid A4 protein homolog； alzheimer disease amyloid protein； amyloid beta (A4) precursor protein； amyloid beta A4 protein； amyloid precursor protein； beta-amyloid peptide； beta-amyloid peptide(1-40)； beta-amyloid peptide(1-42)； beta-amyloid precursor protein； cerebral vascular amyloid peptide； peptidase nexin-II； protease nexin-II； testicular tissue protein Li 2； β淀粉样肽1-42(C端)； 淀粉样前体蛋白(APP)； 淀粉样肽前体蛋白； 磷酸化APP淀粉样肽前体蛋白；
背景信息：
The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.
