基因名：
ARAF
产品别名：
A-RAF； ARAF1； PKS2； RAFA1； ARAF； A-Raf proto-oncogene, serine/threonine kinase； A-Raf proto-oncogene, serine/threonine kinase； serine/threonine-protein kinase A-Raf； A-Raf proto-oncogene serine/threonine-protein kinase； Oncogene ARAF1； Ras-binding protein DA-Raf； proto-oncogene A-Raf-1； proto-oncogene Pks； v-raf murine sarcoma 3611 viral oncogene homolog 1； v-raf murine sarcoma 3611 viral oncogene-like protein； V-Raf小鼠肉瘤3611病毒癌基因同源物(ARAF)； 磷酸化A-Raf；
背景信息：
The RAF family of signaling proteins has three isoforms: A RAF, RAF 1 and B RAF. These proteins are instrumental in forwarding the stimulus generated by mitogens from monomeric G proteins to the MAP kinase pathway. RAF 1 is known to be downstream of Ras and binds to it by an N terminal noncatalytic domain. This domain is conserved in A RAF and B RAF. 14-3-3 is also known to be an activator of RAFs. Activated RAF directly phosphorylates and activates MEK. A RAF is expressed at a very high concentration in urogenital and kidney tissues.
