基因名：
ATOH1
产品别名：
ATH1； HATH1； MATH-1； bHLHa14； ATOH1； atonal bHLH transcription factor 1； atonal bHLH transcription factor 1； transcription factor ATOH1； atonal homolog 1； atonal homolog bHLH transcription factor 1； basic helix-loop-helix family member a14； class A basic helix-loop-helix protein 14； helix-loop-helix protein hATH-1； protein atonal homolog 1； 肠道分化干细胞MATH-1蛋白；
背景信息：
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9.5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
