基因名：
ATP2B2
产品别名：
DFNA82； PMCA2； PMCA2a； PMCA2i； ATP2B2； ATPase plasma membrane Ca2+ transporting 2； ATPase plasma membrane Ca2+ transporting 2； plasma membrane calcium-transporting ATPase 2； ATPase, Ca++ transporting, plasma membrane 2； plasma membrane Ca(2+)-ATPase； plasma membrane Ca2+ pump 2； plasma membrane calcium ATPase； plasma membrane calcium pump； 细胞膜钙转运ATP酶； 钙离子转运ATP酶B2(ATP2B2)；
背景信息：
Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from at least four distinct genes. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export.
