基因名:
ATR
产品别名:
FCTCS; FRP1; MEC1; SCKL; SCKL1; ATR; ATR serine/threonine kinase; ATR serine/threonine kinase; serine/threonine-protein kinase ATR; FRAP-related protein-1; MEC1, mitosis entry checkpoint 1, homolog; ataxia telangiectasia and Rad3-related protein; 丝氨酸/苏氨酸蛋白激酶ATR; 共济失调毛细血管扩张Rad3相关蛋白(ATR); 抗胰蛋白酶相关蛋白(ATR);
背景信息:
Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4